جامعة تكريت - كلية الطب البيطري - جامعة تكريت

The Influence of Lycopene on Interleukin-6, Tumor Necrosis Factor -α , Alanine Aminotransferase, Aspartate Aminotransferase Levels  In Stereptozotocin -Induced Diabetic Rabbits

Entedhar R. Sarhat¹ ,  Siham A. Wadi² , Saba K. Ibrahim²

¹ Dentistry College , University of Tikrit , Tikrit , Iraq

² Collage of veterinary medicine ,University of Tikrit , Tikrit , Iraq

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Abstract

Background and Aims: Hyperglycemia increases inflammation in diabetes mellitus . The aim of this study is to evaluate the effect of lycopene onInterleukin-6 (IL-6), Tumor Necrosis Factor-α (TNF-α) Alanine Aminotransferase (ALT), Aspartate Aminotransferase, levels in diabetic rabbits.

Materials and Method: A total of (25) rabbits of both sexes weighing between 150-260 g were completely randomized in four groups comprising 5 rabbits each. Diabetes was induced by a single intraperitoneal injection of stereptozotocin (35 mg/kg) fed with high fat diet. Animals in group 3,4 which were respectively administered 10 and 20 mg/kg body weight of lycopene for 4 weeks.

Results: Results showed that lycopene administration at all doses significantly (P<0.05) decreased the fasting blood glucose, GOT, and TNF-α levels compared to diabetic control group. Consistent significant increases (p<0.05) were noticed in the level of IL-6,GPT, in diabetic rabbits treated with lycopene  compared with diabetic control group.

Conclusion: This study showed that lycopene can significantly reduce glucose, GOT, and TNF-α and increase IL-6,GPT stereptozotocin induced diabetic rabbits. The results of this study indicate that lycopene is an effective nutritional component to alleviate and/or prevent the complications of diabetes, and these findings can be used as a basis for future studies.

Key words: lycopene, Stereptozotocin, inflammation, diabetes mellitus