جامعة تكريت - كلية الطب البيطري - جامعة تكريت

Experimental Study of Effect of Ginger Ethanolic extract on Oxidative Stress in Alloxan Induced-Diabetic Rabbits

Entedhar R. Sarhat¹, Buthyna A. Abdullah²,   Siham A. Wadi²

¹Dentistry College , University of Tikrit , Tikrit , Iraq

² Collage of Veterinary Medicine , University of Tikrit , Tikrit , Iraq

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Abstract:

The present study evaluated the effect of  ginger on blood glucose and oxidative stress status in alloxan induced diabetic rabbits. Forty eight (control), group II (diabetic control) and group III, and IIV (diabetic rabbits) treated with ginger ethanolic extract as a single daily does. 250mg\kg, 500mg\kg body weight of  extraction dissolve in l cc DW orally for 6weeks respectively. Treatment with ginger significantly reduced (p<0.05) the level of glucose, and MDA, while significantly increased (p<0.05) levels of the GSH,GPX when compared with the control  group. The results indicate that ginger in addition to being anti-hyperglycemic is effective in reducing oxidative stress in diabetes.